Selvita

  Often in the press or online portals , you can find news that someone (usually a lone scientist) has discovered a cure for some extremely important disease. Such news stories appear and will continue to appear, and yet the new drugs they were talking about were as non-existent as they were. How does this happen? What is it that makes molecules, often so promising in laboratory studies, not end up as new drugs? The answer is ADME. But what is ADME ? What does ADME stand for? ADME is an acronym used in pharmacology. It stands for Absorption, Distribution, Metabolism , and Excretion. In short, these are the processes that take place in our body in the context of foreign substances, including drugs. It is how drugs are absorbed, transported around our body, metabolized , and excreted that affects whether a drug is effective (reaches its destination) and safe (does not cause side effects). Why is ADME important? Imagine that you design a new therapeutic molecule. You test ...