Selvita

  Medicinal chemistry is an interdisciplinary science which plays a crucial role in the drug discovery process. In Medicinal & Synthetic Chemistry we follow a highly data-and-hypothesis driven path making meaningful molecules whilst also using productive synthetic routes to bring benefit both from efficiency and from serendipitous discoveries. Success of your drug discovery largely depends on the medicinal chemist’s ability to see the big picture. Key decisions must be made taking into account the whole range of biological, pharmacological and pharmacokinetic data, with an appreciation of the intellectual property space. Our medicinal chemists, armed with knowledge earned in pharma and biotech companies, are skilled in seeing the bigger picture and enthusiastic to contribute to your: Hit identification Hit to lead Lead optimization First in class Back-up chemical series Fast follower approach Preclinical candidate identification Or...

  Translational Research   - Our team develops translational strategies to enable smooth transition of candidate molecules into the clinic. We design and perform in vitro studies on primary human cells and ex vivo assays on fresh  human biological samples, thanks to our collaboration with a network of clinical hospital centers nearby. Patients’ samples are managed in line with the highest standards for acquisition, transfer and disposal of human biological material. The proximity of hospitals we work with allows us to process the samples directly after their retrieval, which is important for preservation of tissue viability throughout the experimental process. Advantages of using patient-derived material for drug discovery process: Studying disease-relevant targets Target relevance demonstrated on actual patient samples Identification of functional consequences of target modulation De-risking candidate selection Early identification of com...